The cytology diagnosis of the ovary cancer includes to shed off a cell check diagnosis and thin needle to wear a sting to absorb a cytology check to diagnose two parts.Shed off a cytology check to used for gynecology clinical have already counted a decade.The thin needle wears a sting to absorb a cytology check, about 20 in the last yearses are in the diagnosis of various tumor also drive extensive adoption, this method has to the ovary tumor diagnosis certain value, relapses the diagnosis that tumor and lymphoid knot transfers cooking stove to the later period, can not only definitely diagnose, but also keep some otiose Pou stomaches from fishing for.
A, the cytology diagnose
(1)shed off a cytology check:Can obtain to shed off cell specimen from three aspects, include:①The vagina, neck takes care of and temple chamber;②Stomach water or belly cavity infuse to wash a liquid;③The womb rectum sinks cave wear a sting to absorb.
(2)the thin needle wear a sting to absorb a method check:Clinical draw up to diagnose for the ovary cancer and basin the chamber blazes a different of the film inside the chamber womb of sex lump or basin disease, but have a difficulty in discriminating diagnosis, can be carried on wearing a sting to absorb a cell check by vagina, rectum and belly, and can from the shallow form lymph knot such as lock bone up withor stomach the ditch lymphoid knot obtain a cell check.Check after the peritoneum lymphoid knot, then can lend fluorescence clairvoyance and B super or the CT scan to guide to wear sting part and wears the accuracy that the sting absorbs a check by exaltation.
Two, the shadow elephant learn diagnosis:Including B is super, CT and MRI check.The prospects learns diagnosis to continuously develop, and has instruction meaning to the treatment of ovary cancer in recent years, these check method, can the cent of in aid of assurance ovary cancer expect, and can borrow with with visit, help understanding didn't relapse and estimate to prepare behind.
(1)the B super check:Up to now, B type super voice scan to check still for the basin chamber tumor a head to choose of sieve a diagnosis technique, it can show a part of chamber lump, size and quality, is a bag or a materiality.If there is an obvious nipple Tu rising and close by the organ implicate, can hint malignant tumor.Can also classify stomach water is as swollen as huge ovary bag.In addition can also help the proliferation part of making sure the ovary cancer such as liver knot stanza, aorta side the lymph knot swollen big, the big retina transfer cooking stove etc. and help the clinical cent to expect.
(2)the CT check:The function of CT check is:①Can be accurate to show that a chamber dissects structure as usual and unusually;②Basin the fixed position of the chamber lump with settle sex;③Certain tumor cent expects;④The instruction establishes treatment project and estimate to prepare behind;⑤After the Shu with visit a reexamination, contributing to understanding hasn't relapsed;⑥Contribute to a clinical observation chemotherapy and put curative effect after treating, and twice or again the Pou stomach fish for ex- remain the variety of tumor;⑦Carry on CT to get involved sex check, such as CT direction next the thin needle absorb to live check.But the CT check is still difficult to discover a second clinical focus, namely small focus, therefore the CT diagnoses feminine gender to replace Pou stomach to fish for.
(3)MRI check:MRI useds for clinical, have already displayed its obvious advantage:①Don't use ion emanation, to human body didn't because of the emanation cause of damage;②Can arbitrarily choose to scan flat surface and direction;③The soft organization contrast surpasses CT;④Can to the pathological changes accurate fixed position;⑤Help the clinical cent to expect.But because of equipments and check expenses Gao, so had better first sieve with the super voice check behind again certain whether demand again further applied MRI check.
Three, the tumor mark the measurement of thing:The immunology check is the new path that diagnoses tumor and use to more ideal method of examining the tumor sign thing currently.But currently but speech, ovary malignant tumor's marking sensitivity and particularity of thing all can not satisfy the demand that diagnosed in early days and much use to examine a treatment to moderateor treatment empress of condition variety, for assess curative effect and discover in time that the tumor relapses to provide basis, don't lose opportune moment ground to adopt effective treatment measure thus, depend on this to raise an existence rate.
(1)cancer antigen 125(CA125)
(2)cancer Pei antigen(CEA):The method that examines CEA currently contains 2 kinds, a kind of is an adoption to project immunity diagnosis method measurement blood CEA, 1 kind is to adopt the immunity set turns a method examination cancer organization CEA, these two kinds of examinations of clinical result, all has already denied to transfer and relapse with the organization type, clinical cent of tumor after expecting and the ratings, curative effect and treatment relevant fasten.
(3)A foetus egg white(AFP):Whether AFP goes up, be decided by whether the tumor organization has inside the Pei Dou lump composition and have particularity value, or mix the yolk bag composition in the lump to the immaturity Ji foetus lump, the mixture asexuality cell to the lump of Pei Dou inside the ovary(ovary bag lump), all meaningful.When tumor relapsed or transfered, even if exist small lump cooking stove, AFP will as well again go up, other check method sensitive.
(4)person the floss film urges sex gland hormone(HCG):Measurese sufferer the serum β -HCG, can help the diagnosis ovary floss film the cancer and companion have a floss film the germ cell tumor of the cancer composition, such as ovary pure asexuality cell lump.May also precision reflection cancer cell of amount, so be also the index sign that observes condition variety and anti-cancer treatment effect.
(5)the lactic acid takes off hydrogen Mao(LDH):LDH together the achievement Mao compose to have certain meaning to the diagnosis of the malignant tumor.
(6)the saliva is sour(SA):The SA dynamic state observation contributes to changing a treatment project in time.
Four, project immunity to show an elephant technique:Currently, the radio checks the research of the plain marking single gram of Long antibody(mabs) and has already caused the very great interest of the experts, it is a kind of anti- tumor that checks plain marking by radio and it the antibody of related antigen, used to living creature guided missile, show an elephant for tumor masculine gender, be called tumor immunity to show elephant diagnosis technique.Carry on positioning a diagnostic new technique to the ovary cancer in recent years.
Five, the flow type cell Shu:The tumor DNA quantitative analysis often has the chromosome analysis, static state cell the Shu and the flow type cell Shu(flow cytometry, FCM) three kinds of methods, the study tumor content variety had better choose a FCM method to the clinical assistance value, that method is to pass analysis DNA histogram understand tumor DNA content.The ovary hands over the boundary tumor DNA the content and organization appearance, clinical cent expect and relapse related, ovary cancer DNA judgment and estimate of choice, curative effect of quantitative analysis to treatment project have bigger assistance value after preparing.
Six, the lymphoid knot build a shadow check after the peritoneum:In order to estimate that the lymphoid knot hasn't transfered.
Seven, the belly cavity mirror check
The belly cavity mirror check directly peep a kind of check method of belly cavity, can see a basin chamber lump and counteract naked eye to discriminate;If can not discriminate, can be also carry on living an organization check.And can directly observe whether the horizontal Ge, liver and retina and the peritoneum surface has already transfered cooking stove, can put forward according to this second clinical sow a loose circumstance.Can absorb stomach water in the meantime as well, if have no stomach water, can be infused physiology brine by belly cavity mirror, then take belly cavity to flush a liquid to carry on a cytology check.Therefore belly cavity mirror the diagnosis in the ovary cancer, discriminate diagnosis and divide mid-term all have important value.The belly cavity mirror has already used at examine for two times fishing for of the ovary curative effect Shu in, although can not replace for two times fishing for of the Pou stomach Shu,contribute to sentence a chemotherapy after exist of the lump cut off or can not cut off, is still that the focus have already extensively sown to spread.Its adaption is:①Useding for chooses two cases that the Pou stomaches fish for to avoid already and extensively sow to spread not the cases of ability surgical operation but go Pou stomach surgical operation.②Can understand the sufferer's reaction to the medicine during the period of chemotherapy;③Accidentally can discover two Pou stomaches fish for result feminine gender of relapsed a focus in early days.
Eight, the Pou stomach fish for:Pou stomach's fishing for is an ovary cancer to make sure the diagnosis and surgical operation divides to expect the most dependable method.
The ovary cancer diagnoses mode
3.11.2009
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