The nose malignant proud flesh is swollen

※All say
The malignant proud flesh is much more swollen to begin from a nose of department, gradually spread to face centerline after, is 1 kind with carry on sex bad dead to ulcerate for clinical characteristic of the seldom seen proud flesh is swollen.The cause of disease of this disease didn't be clear, the pathologic check much organized for the chronic non- particularity proud flesh with bad die, among them have the burning disease cell of various compositionses gradually.Because the pathologic entity is each different, past it assigns name to with classification numerous, such as bad dead the proud flesh is swollen.Causing death sex centerline proud flesh is swollen, the noodles central part deliver sex proud flesh especially swollen and the centerline malignant net knit cell to increase to living a disease etc..Clinical commonly use malignant proud flesh currently swollen.
※Diagnose
This cause of disease according to clinical performance and organization pathology and laboratory check, diagnose not difficult.Diagnose important point:①Any occurrence carries on sex proud flesh to ulcerate in nose department and noodles central part bad dead, all should first consideration originally disease.②Pathologic check:Present the chronic non- particularity proud flesh swollen sexually transmitted disease to change, see in the meantime the different type net knit cell or nuclear fission mutually, can immediately diagnose this disease.③The part injures severity, but is all over still good.④Part lymphoid knot not generally swollen big.⑤The laboratory checks:The white cell counts low, the red cell sinks to decline a rate speed.⑥Later period patient's often hasing continuously sex tension and relaxation is hot and carries on sex emaciated and crock up all over.In early days diagnosis treatment, better after preparing.Clinical should notice and nose department tubercle, atrophy sex rhinitis, and malignant tumor...etc. to mutually discriminate, the only method is again and again to live check for many times.
※Cure measure
Mainly adopt comprehensive therapy currently.
1.Support therapy patient all over consume a little bit greatly, strengthen a nourishment, blood transfusion to lose a liquid and rectify whole body to crock up appearance, is very necessary to cure further.
2.Steroid hormone and antibiotic therapy to activity period patient, the nose face festers and crocks up all over and keep on hot, the Na eats poor, the proper adoption big measures the skin quality steroid hormone to mount sudden attack a treatment, go to nose face and whole body symptom amendment after, again change to small amount of to maintain to clinical to cure.Should give the antibiotic control the infection in the meantime.This period, currently can normal regulations application wreath already bad nitric Mao(CCNU) treatment, its function similar the alkane turn, can repress nucleic acid and protein to synthesize in the body and show results quickly, with reduce fever effect the best.The adult takes orally a 120 mgs, 3~5 Mondays each time, time, total 5~6 times, the total measures to 600~840 mgs.
3.The anti-cancer medicine therapy clinical useful anti-cancer medicine cures experience report way of this disease.If use 6-the sulphur radicle Biao purine adds the skin quality steroid hormone, ammonia A Die purine to make artery outside the neck to infuse to note and takes orally, after change to 5-the fluorine Mao Mi Ding, also useful plain match for winning glory mildewed put to treat, the curative effect is very good.
4.Put to treat
The malignant proud flesh is swollen to project line sensitive, so put to treat is the main method that the treatment originally gets sick currently, adopt cobalt more-60 project light upon a method, the total measures for the 60 Gies(6000 rads) and relapse can repair to shine on.Can also project light upon with the deep department X line cent time, each time(129~387) the × 10-4 Cs, next day or everyday once, the total measure(2580 ×s 15480) the × 10-4 Cs not etc..
5.The part treatment festers to the nose face, knot Jia, and abscess...etc., should sweep every day, such as merger abscess, can cut open to lead to flow.
※The cause of disease learns
Don't be clear.According to clinical calculate this disease as tumor with pathologic characteristics.Have the abnormal condition reaction, oneself various theories, such as immunity and infection...etc..
(A)type scholars with many tumor theory think that this disease is the malignant tumor of lymphoid organization system.The pathologic organization is similar to net cell tumor or lymphoid lump, there is tumor increasing rare abnormal shape cell and nuclear fission mutually, but have no bad dead afferent and check big and small afterbirth more.Because the pathological changes is limited by nose department and breath way, and goes to the later period of disease, body everywhere all can show a same pathological changes such as the internal organs, lymphoid knot and marrow, the very much resembling malignant tumor transfers.Majority of patients match tumor theory towards projecting line sensitive, , but still lack up to the present clinical really slice proof with pathology.
(Two)abnormal condition reaction or the oneself immunity recent years research think, this disease may be a kind of from earlier period of abnormal condition reaction but cause afferent pathological changes, namely blood vessel to the allergy of germ toxin, pole Arthur bad dead.There is immunity globulin in the hair thin afferent wall depositing, and expect in the disease activity the patient examines an immunity in the serum compound, applying immunity depressant the treatment can make the symptom alleviated.The immunity fluorescence experiments and discovers a small ball base of kidney there are C3 and IgG on the film.Give or get an electric shock to have the immunity compound the body kind thick grain-like in shape thing inside the mirror check base film, the wreath immunity is compound to go up, past someone thinks the nose department malignant proud flesh is swollen, the knot stanza artery surroundings burning and Wegener the proud flesh Be swollen to belong to the same a type of disease, only clinical performance different just, three is all oneself immunity disease.The clinical adoption skin quality Chun treatment effect shows Zhao and as well supports this theory.
(Three)the pathology of the infection theory this disease much present chronic burning disease change, but again hard affirmation has particularity to germ, virus and fungi.The recently research discovers that at adopt the malignant proud flesh swollen organization carries on cell development and patient in the serum, all find out a gram of Sa the strange virus small body, so think that this disease has something to do with this virus infection.
※The pathology changes
According to the pathological changes characteristics and the pathology change, can induce to 2 types:
(A)cheek tumor type
The pathological changes is more several than a nose department and as well have a hair at the last Mao and swallow department, result and nose department.The pathological changes is mainly located on face centerline and the top breath way, with carry on sex proud flesh to ulcerate bad dead is lord, its destructiveness even extensive, can invade and bone and cartilage, even disfigure.The later period patient dies in big issue of blood more or crocks up.The pathology variety difference of this disease is mainly more big, Be seen to the following 4:①The non- particularity burning sex proud flesh organization contains the burning sex cell of various appearanceses;②The non- particularity burning sex proud flesh organization contains many big and small afterbirths;③The non- particularity burning sex proud flesh organization contains a great deal of organization cell;④The non- particularity burning sex proud flesh organization contains obviously bad dead.Above-mentioned 4 present hybrid existence more, and often regard lymphoid cell as principle and mix more syrup cell and the amount different organization cell.These cells take blood vessel as center and there is the tendency to surround blood vessel gradually.Though have in the different type of etc. in these cells,still can not diagnose for the malignant tumor.Wegener the proud flesh swollen pathology variety although also right and wrong particularity the proud flesh is swollen,its characteristic is to have already checked big and small afterbirth and bad dead more blood vessel burning, this is that the malignant proud flesh is swollen and Wegener the proud flesh swollenly discriminates diagnosis standard.
(Two)abnormal reaction type(oneself immunity type) the Wegener proud flesh Be much more swollen to is this type of and usually is divided into to limit sex and whole body 2 kinds.BE mainly blazed a disease by afferent and allergic to.It's swollen to deliver sex proud flesh more, besides which, also the performance carry on sex to ulcerate for the bigotry bad die, can limit at breath of way, and can involve in each dirty machine of lung and whole body.Infringe upon lung then performance in order to deliver sex knot stanza more, the often free hole forms and involve in a kidney then performance for limit sex kidney bad die, the kidney small ball kidney burning.Can also cause whole body the blood vessel injure, can have the fiber exudation the thing in the blood vessel and proud flesh organization.The proud flesh of Wegener is swollen of ulcerate bad dead much occurrence at the body inside, can involve in organs such as nose, last Mao, throat, windpipe, kidney, Pi, adrenal glands and lung etc., the patient much dies in all over crock up with urine poisoning disease.
※Clinical performance
Stewart is divided into three periods: malignant proud flesh swollen clinical performance:
1.The ex- Qu expects for generally catch a cold or nasosinusitis express.The by fits and starts nose jams, companion water kind or take guts secretion.May also the performance is a nose aridity knot Jia.The part checks for generally burning the disease express and separate in the nose can appear the proud flesh swollen sex ulcer.This expects to keep on for 4~6 weeks.
2.The movable period nose ventilates Chang not or completely jam, there is Nong Ti, often have bad smell.Whole body circumstance fair, abnormal sweating, the appetite is worse and often have low heat, the minority are hot and use general the antibiotics cure invalid.The partial check sees the nose glue a film to swell, debauched with to ulcerate, assume proud flesh-like in shape, the surface has the grey color the bad dead.Much and first involve in AN in nose or separate in the nose, obvious can to the nose external inflation swell up, the pathological changes development can result in to separate bore hole in the nose or Mao department boring.This expects to keep on for week to few months.
3.Eventually the patient is weak in last phase, the quality of bad disease, the part disfigures.The nasal cavity glues film, cartilage and bone substance and surroundings organization(such as face, eye socket and sum department even Lu bottom) serious extensively the break, eyelids and conjunctiva swell, the eyeball is outstanding, sight decrease, end because of crock up, bleed or erupt meningitis but die.