The gene treatment carries to realize to stir up cancer

The gene treatment researcher discovers a kind of is iner common use than treatment the gene load in the virus of small rat to carry a body to contain side effect, will cause liver tumor.Some experts argue to say, make use of this kind of to carry the clinical studies that the body carries on very safe.
Someone once worried the side effect that the gene treatment has already caused cancer.Several year agos, a gene in France cures an experiment in, 1 kind converses to record virus to cause a leukemia in three children(ScienceNOW, 14 January2003s:).In 2001, the University of Washington MarkSands in the molecular biology house, once accepted the small rat of virus(according to calculate more safe) while being born, middle age develop a ratio of liver tumor higher.Empress a detection makes American food and drugs inspected administrations(FDA) to stop two clinical studies(Science, 23 November2001s, p.1640:).At an expert the group makes sure problem the virus-gland related virus(adeno-associatedvirus, AAV)-after doing not cause cancer, the experiment just can recover.Contrary, some persons think, in the experiment use of knock in addition to the article fastens small rat incline toward more to contract cancer.
Now, Sands the experiment proof of the group expresses, the gene treatment carries a body to really stir up cancer.They to knock in addition to small rat and normal small rat injects AAV to carry a body, as a result a set of ex- ratio that develops a liver tumor is 33%-56%, empress a set of the ratio that develops a liver tumor is 4%-8%.The DavidRussell of the University of Washington laboratory looks for to carry a body in the middle of coming from 6 tumors of small rats.In 4 tumors, carry a body to insert chromosome 12, open a few kinds cancer- related gene, the detailed contents publishes on July 27 a Science magazine.
These detections aroused people to carry the concern of the safety of the body clinical usage to AAV.Russell says that we should pay attention to the balance of of risk and benefits at least.
State university PhilipLaipis in Florida once observed to accept the tumor of small rat that AAV carried a body treatment as well, agreed that making use of is similar Gao Ji Liang AAV the Ba is to the liver cell.The liver cell more easily absorbs Na AAV to carry a body than other type cells.Laipis says:"AAV probably integrates you not to hope that the that it integrates orders."
Other researchers but hold a doubt to this research.Stanford University university MarkKay emphasizes that haven't discovered tumor rate ascension in the middle of accepting several thousand small rats that liver AAV carries a body treatment, have never discovered a tumor incidence rate in the middle of accepting AAV and curing 6 years or above dog as well ascension.Once participated in a clinical research, made use of AAV, the liver injected Kay that the rule of law treated hemophilia to say, the tumor prognosticated by Sand laboratory may be high amount of to cause of, but actually fastens with the article of small rat used and is a newborn small rat relevant.Expert in 2001 group representative director and University of Pennsylvania PhilipJohnson agree with to this deep watch."Their experiments have very the place of reason."
Anyway, 17 under way of AAV carry the body experiment should be more safe, because their Ba to of is an other organization, like brain, see retina etc..FDA spokesman KarenRiley said that the organization can't carry on commentary to personal research.