The immune system is unexpectedly a cancer accomplice

The immune system behaves a body to healthily protect to drive to escort to have become a kind of common sense, however, in recent years a series of and important detection but make the owner tumbled glasses:Participation burning disease reaction, the immunity cell helping the wound to heal be unexpectedly as vitally related as the depravation of tumor, they will help the tumor to grow and help cancer cell to transfer other organizationses.Cut off immunity cell and the contact of the of tumor from here, become new anti-cancer battle main melody.
More than 500,000,000 year agos, for the sake of resist the external world hit, our ancestries evolved a set of defense weapon:Some special Mao and proteins.If microorganism and toxin broke the external defense line(like outer shell) of a certain cold Wu Ji's animal, these immune system member in earlier period will mutual cooperation, to illegal entry launch violent attack-break microbial cell wall and expel chemistry toxin animal body or directly gobble up and digest them.After invader is completely exterminated, the immune system starts repairing damaged cell.If some cells weighed a condition of the injury, immune system would destroy them.
This kind of blazes disease immunity's reaction obvious to animal healthy importance, therefore, even if experienced the evolution of aeon, immune system of very multi-function and the characteristic be still protected to stay.The research discovers that be regarded as the fruit fly(fruitfly, 1 kind of fly, in common use mode living creature) low etc. living creature like this, own of a lot of immunity genes all and mankind's homology, vertebrates and non- vertebrates are also such-is the same living creature in the ancestry of 500,000,000 year agos, mankind and these animals.
Many in the last yearses, the congenital immune system almost has never caused the value of the immunology house.They think that the so-called congenital immune system is just a group of living creature members, their functions are to annihilate any foreign material that wear over the animal skin or the outer shell.The immunology house concentrates energy an adaptability immune system at more deluxe day after tomorrow.This kind of system can aim at a certain and foreign material and call to correspond antibody and other"weapon"s to identify them, also the destination carry on an attack, the congenital immune system then has no this kind of to aim at sexual protection action.
But at the past 15 the middle of the years, the congenital immune system gets into the visual field of immunology house gradually.Burning the disease reaction is the sign of the congenital immunity characteristic, it almost forms with all chronic paroxysms relevant:In addition to type rheumatism the arthritis and gram Luo's boon is obviously far-gone to blaze a disease and also included diabetes and suppress mortal diseases, such as Yu disease, heart attack and stroke...etc..(pay respects to page 49 side column)The last few years, the researcher evaluated burning disease reaction and the relativity of of cancer in detail.The Luo uncle of black virtuous(Whitehead) biomedical science graduate school in White in M.I.T., the United States is especially.A.The Wei says because of the shell space(RobertA.Weinberg):"In our research realms, the relativity of of the burning disease reaction and cancer is already a focus problem."For this kind of research point of variety, his textbook in he's copy chief 《cancer biology(emendation version) 》in made point treatise.
The explosion of the cancer is a continuous process:A series of heredity the variety cause a group of cells to excessively propagate, to surroundings organization hit, form a real malignant tumor;Some tumor cell"discomfort is at the present condition" transfer to arrive farer organization, long new tumor.For long time, our understanding is only limited by this.Research point of variety mean, cancer biologist and immunology house have been already known and form process in the cancer in, immunity burning the disease develop importance of regulate a function.Organizes in the pathological changes real before becoming to have the tumor that invade sex, some cells that have wound repair function will be transfered pathological changes organization, here, they "Be forced" accomplices who become the malignant cell, acceleration cancer explosion-positive such as the researcher describe of so:Inheritting the harm is "leading fire Suo" and blaze disease reaction"the fire up sprinkles oil" is then.
At 《cancer biology(revise a version) 》medium, the Wei thinks because of the shell space, the tumor isn't a simple mutation cell aggregation, it still has a system that brings up its growth, a tiny environment(imply various immunity cell and maneuver the chemistry signal of interleave conduction path) that is suitable for a tumor growth and presents the blood vessel that the net distributes.In the human body, the tumor is thought to is "illegal organization", since not participate in transporting of blood, also can't clearance body endotoxin, one heart for oneself"seek private interest".
This whole new look suggests and cure cancer probably don't need to uproot all cancer cells.Eliminating inflammation the anti-cancer therapy can prevent°from having the cancer changes trend of the cell development is a real cancer cell, or obstruct cancer cell to spread in the body.Adopt this kind of therapy, the cancer sufferer's existence several rates should have an exaltation.Li a kind of insect.M.The database Sen Si(LisaM.Coussens) is an University of California in the United States San Francisco divide the cancer biologist of school, she comments on a way:"I don't think don't want to cure for good cancer can not, have no a necessity to do like this.If we can control cancer and safely finish leading whole life, was already an important victory."
The immunity defendoofs
The anti-cancer member in the scientist's eyes, but is proven is cancer acceleration, even still have the experiment result the enunciation, there is no the help of immunity cell, the tumor can't worsen.
Want to comprehend a burning disease a relationship with of cancer, must make two pure basic problems first:How machine body is make a reaction to the invader;When burning disease reaction keep on time lead long, the normal wound heals how the process accelerate a cancer to change progress.If you carelessly trampled to a nail, some germs would seize an opportunity to drill into body from the feet bottom, but they can not stir up trouble in the human body, because on getting into a human body, the germ will be subjected to violent attack of a group of immunity egg whites and cell.Participate in defensive immunity egg white in addition to antibody, also have 30 to grow to repair body egg white.These egg whites are 1 of other human body defense mechanism to add, therefore get"repair a body".They can cause germ's fusing, while the germ gobble up cell and then will start out inside the human body once fusing, swallow the cripple remaining part of germ.
Once meeting guest who comes uninvited, huge bite cell(macrophage) and love a neutral grain of cell(neutrophil) meeting will they the whole deglutition, the digest drops.In addition to above-mentioned two kinds of cells, gobble up cell to still include nature to kill to harm cell(naturalkillercell), fatty big cell(mastcell) and love an acidity grain cell(eosinophil).The wound heals in addition to wanting to exterminate to invade germ, also need participation of blood platelets:They from be full of blood vessel of inside the quality layer move to the epidermis damaged place and make the blood solidified.Then, under some functions of Maos, a great deal of protein forms a complex network and is solid to settle down the skin cell.The wound starts knotting Jia, skin and then president of association return to original kind and blaze disease battlefield also gradual dead silent come down.However, blaze a disease to respond sometimes not real stop.Not only is a skin, any organization all may because the existence that the cause body, toxin or heredity hurt but long-term inflammation, become paroxysm"hotbed"s, such as heart attack and cancer...etc. thus.
In addition to a defense line, the vertebrates still has other deal with a cause of body of"weapon":The adaptability immunity should answer the member characteristic that can identify invader, then have already carried on an attack to sex ground.The main performance of this task is B cell and T cell.The antibody member of B cell manufacturing since can directly "suppression" a cause body as well as beat on the cause body up print to record, make other members or cell exterminated a cause;The T cell can induce the cell being been infected to commit suicide, or secrete special chemistry material and guide the activity of other immunity members.
A great deal of proof suggests that the depravation of chronic burning disease and some tumors has close contact.In fact, very early the researcher doubt that burning disease and cancer exist a certain connection.In 1863, famous Rudolf in the pathology house in Germany.The Wei Er roar(RudolfVirchow) discovered immunity cell in the malignant tumor;In 1978, the Italian Milan university subsidiary kindness to fellowmen clinical hospital(HumanitasClinicalInstitute) of the Er shell give.The Man gives tile Ni(AlbertoMantovani) in the neighborhood of some tumor and observes congenital immunity cell and has the tendency of the gathering;In 1986, the cancer biologist of American Harvard medical college hello virtuous.F.The virtuous fertile summer gram(HaroldF.Dvorak) points out that the cancer is "can not heal of wound".However, there is still a biologist insisting thinking, immune system not only can protect machine body's doing not need be subjected to hit of the cause body, also will pick out to have the cell that the cancer changes to incline to.Exactly which is right and which is wrong?After the tiny environment that cautiously observed cancer surroundings, the scientist seemed answer.
Anti-cancer still keep causing cancer?
On closing to tumor, it is huge to bite cell and then will be subjected to tumor of the cell sends out of the interference of signal member, become the rebel of immune system, provide convenience for the growth of tumor.Exactly is what member own such magic?
At the end of 90's in last century, University of London in England Mary the Fu Lang of the queen cancer institute for research west silk.Powell gram the Wei Er(FrancesBalkwill) studied a kind of egg white member in the human body.This kind of member is more similar than hormone, is a kind of immunity signal member, higher in the density, can kill cancer cell, therefore the scientist is called the tumor bad cause of death son(TNF) to it.But, when the tumor bad cause of death son of low density is been detained to tumor China Times over a long period of time, but may have a clearly contrary function.In the middle of experimenting at a time, Powell gram the Wei Er knocks in addition to small rat body up code the gene of the tumor bad cause of death son, can not make it synthesize bad tumor cause of death son.Experiment result amazingly:The small rat unexpectedly became the cancer"insulator"!She recalls a way:"This result caused in science field a 'earthquake', all scientists' all silly eyes that the tumor bad cause of death son regard as anti-cancer medicine to study, the originally anti-cancer member became cancer acceleration a while."
Today, the gene knocks in addition to the technique has been very mature and optionally knock in addition to a certain gene of small rat, can verify the concrete function of that gene.We can make use of this method and study cancer with blaze the relativity of of disease.
In 1999, database Sen Si and way the space pull Si.Admire Na sweat(DouglasHanahan) and Ze Na.The Wei cloth(ZenaWerb) announces an article to point out and turns the cancer gene of the gene small rat even if is activated, produce the cancer becomes ex- to organize, as long as there is no fatty big cell(mastcell, a kind of congenital immunity cell), still can't form real tumor.In 2001, the hero Fu of American Einstein's medical college in.W.Wave pulls virtuous(JeffreyW.Pollard) cultivated with colleague some easily suffer from breast cancer of turn the gene small rat, although can discover to have the organization that the cancer changes and inclines to on small rat, as long as have no huge bite help of cell, these organizations aren't thoroughly worsen.
New detection not to traditional standpoint of completely negative.Actually, the immune system is "double blade sword".This only next to brain of the cell of the system and the complicated degree of the member network, and the place of existence self-contradictory:Sometimes it to the cancer bright"green light", but sometimes it again bright"red light".Some congenital immunity cells for example kill wound cell naturally, really can repress the growth of tumor.But other immunity cells are all "the teacher of justice" that exterminates tumor at ordinary times and only have to be tiny environment to be placed in burning disease appearance, just probably "give support to a tyrant".And, the burning disease reaction is to will cause the formation of tumor in all organs.Concerning burning disease with pass blood proliferation of the relation of of cancer still treat further assurance