Organize the member mechanism that the repair causes tumor occurrence

Experiment enunciation that makes use of small rat to carry on recently, the human body really can stimulate the growth of tumor for organizing hurting producing of nature of repair reaction, and this also is burning disease reaction and of the cancer hint a new of the connection on the molecular biology.
Researcher RuslanMedzhitov and his colleague SethRakoff-Nahoums of medical science graduate school(HHMI) in HowardHughes discover that one urges the egg white of growth of bowel cancer, under the normal circumstance this egg white participation bowel organization of hurt a repair.Yale University the scientists of medical college announced this detection on Science on July 6, 2007.They say that this new of the research will help the comprehension of the scientists and probably finally control this to promote the organization of tumor growth repair path.
Medzhitov and Rakoff-Nahoum studied a function of egg white that is called Myd88, this egg white participated in a member signal thoroughfare of causing the bowel department organization repair.It can accept to is called the key immune system that the Toll kind is subjected to a body to regulate activating of egg white signal.
"Very early, people think organize a repair respond the possibility has something to do with tumor taking place process and fastens, because the tumor grows to be also seen to a kind of organization that is free from and regulates and repairs, " Medzhitov says, "so we suppose the Toll kind is subjected to the organization repair reaction that the body causes to take place and have a function in the process in the tumor."
In their experiments, the researchers used the small rat of adenomatouspolyposiscoli(APC) gene mutation, this gene with big parts of mankind colon cancer of the hereditary and self-moving is closely related.But be like mankind, taking the small rat of having this variation gene will have the growing of organization of the abnormality bowel and tumor happen.For examining Myd88 in the tumor nascent function, the researchers design created some small rats that can not produce Myd88 egg whites.
The these Myd88 and APC genes all took place the small rat of mutation than those imperfection the not normal bowel of the APC small rat organize growth and tumor the occurrence all have to be little.But discover after cautiously comparing the small rat that two articles fasten, their occurrence is called tiny gland lump of the number of structure is similar before the cancer, but if imperfection Myd88, so a lot of these tiny gland lumps can't take place and become tumor further.And this also tells the researchers, growth and development of Myd88 rightness tumors contain influence, but for cancer of the earlier period take place not.
"This detection hints we probably the Myd88 involves of go by way of the start that can pass to control an organization repair reaction to control the occurrence of tumor."Medzhitov says that" is in the normal organization, once organizing repair reaction is induced occurrence, it can add the organization of good harm, then come to a stop.But under the sistuation that there is the mutation of cancer-causing, first tumor's growing is thought is to built-up damage but stir up the occurrence of organization repair reaction.This caused a vicious cycle:The organization repairs the growth that the output cell will be used for tumor regiment, while the larger tumor regiment will be thought to is a larger organization damage and make the organization repair responded to provide more growths that the cells are used for tumor thus."
The researchers made use of a totally different bowel lump formation model to further confirm that the Myd88 is in the cancer growing function.If their detection the time that gives a kind of chemistry carcinogen that is called azoxymethane to these small rats, the tumor of their growth wants to compare the small rat to is little as usual.
Medzhitov says that is having already confirmed Myd88 after being the important start factor that organizes repair reaction, the research direction of his laboratory next move will be look for can at organize a repair to complete to afterwards turn off this reaction of member signal."If we can authenticate a , this negative control signal, probably can pass to provide such a signal to cure tumor, " Medzhitov says.Look for the tumor makes use of of trigger the signal of organization repair reaction is also one of the research directions in future."If we know what that signal is, we can tried to moderate it and obstruct the tumor organization repair procedure thus, while this can also help to repress or obstruct the growth of tumor."