Why will the cancer transfer

3.10.2009

The cancer cell transfers may because of waking body uping in the embryo of soundly asleep develop related transcribe factor to.
Generally speaking, cancer cell's carrying on transfering will is divided into a few stages:The first stage is called invasion, the cancer skin cell will loosen the conjunction of of opening the cancer cell in this stage and make the cancer cell"heavy get free" but can move to go to other places.The second stage is called inside ooze, the cancer cell once wears an afferent or lymphoid tube of inside the skin get into circulatory system.The third stage is called an outside to ooze, in the middle at this stage, after circulatory system of the trip baptize of Xin, a Chinese family name save, will once wear capillaries of inside the skin cell arrive other organizations.The stage of end is the New Continent of these cancer cells to immigrate, among other organizations multiply greatly the malignant tumor that healthy and strong formation transfers.
Although there has been research disclosing one being some and transfering the process related gene currently, however most of the researches all inject the cancer cell into circulatory system, thus then be in need of and infringe upon and inside ooze the function related gene research.The research group led by the bosom virtuous RobertWeinberg in the sea graduate school of M.I.T., announced to transfer with cancer recently related the research in early days result.
First they use a hot microarray technique come analytical will the gene of the cell of rat breast cancer transfering express, from medium they find out an important of transcribe factor:Twist.In the some processes that transcribes factor to develop in the embryo, carry to cause the task of cell ambulation and organization reorganization.And similar cell ambulation and organization's remoulds situation will also take place when the tumor transfers.
They discover that Twist will make to is attached plain E by the sticky calcium adjusts to control of cell sticky attach function expiration, and produce the last skin- quality conversion of last skin cell.And is stopped Twist cancer cell of performance its degree for transfering will lower, and also have a decreasing phenomenon at the cancer cell within circulatory system number.Moreover in the invasion in mankind's breast cancer little leaf the cancer Be in the middle to also observe Twist to repress calcium to stick to attaching the performance of plain E.
Therefore Weinberg waits for someone to calculate, cancer cell of so can carry on transfering, may be because wake body up in the soundly asleep already a long time, the gene be responsible for embryo earlier period type's developing, start related procedure thus, therefore drive the terrible ability for transfering.
In the future at clinical up probably can develop medicine with the performance that repress Twist, this gene, keep tumor from transfering;Again or can by screening out these genes discovered the tumor future alignment in early days, and give appropriate treatment.Probably later cancer no longer is so make person terrible great calamity, and will become another chronic disease also uncertain.

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