The chemotherapy project of gall bladder cancer

(A)Get involved a chemistry treatment
In addition to outside developing direct invasion liver toward the bag later period gall bladder cancer, and pass a lymphoid tube to transfer to area lymph in the liver door knot and the liver lymphoid knot inside 12 bowel ligamentses, cause liver door to Yi head area lump with jam sex jaundice;Can also through blood way to liver inside and dirty machine in the distance transfer.The development outside the bag of above-mentioned gall bladder cancer greatly lowered a surgical operation excision rate, the past existence rate was the lowest.Adopt comprehensive measure, kill to put out or limit a bag an outside gradually or transfer cooking stove, create opportune moment to fight for the Ⅱ period surgical operation excision;Or match surgical operation, fight for lending support to measure to kill to put out after operation survive lump cooking stove or cancer cell regiment, is the point of research in recent years, developing among them the powerful measure of important function is(super) a selectivity gall bladder the artery or liver artery infuse to note a chemotherapy technique.
1.The selectivity artery infuses to note a chemotherapy
Adaption:Opposite limit, only rightness of close by livers directly and gradually of progress period cancer, in order to promise surgical operation excision and excision to destroy killing of lump cancer cell to put out behind, should before Shu Shu after carry on artery to infuse to note a chemotherapy respectively.Liver gradually and liver door etc. pours flattering progress to expect cancer artery's infusing to note a chemotherapy is the effective measure that controls the cancer swollen development, should match with other measure to periodically carry on.
Taboo certificate:Body severity weak, the liver, kidney, heart and marrow function aren't obviously whole, isn't suitable for to infuse to note a chemotherapy.
Method:
(1)the patient prepare:Surgical operation or wear a sting to live the pathologic type of checking the explicit cancer to use a medicine to sex.The image learns the data explicit tumor to involve scope and puts the artery of tube by instruction choice and hereafter face to measure to check against curative effect, had better be CT or MRI, meticulous of super voice the check can also satisfy a request.Other blood vessels build the normal regulations preparation of copying the Shu.
(2)the apparatus prepare:Together liver cancer.
(3)infuse to note a method:Similar to liver cancer.The gall bladder artery originates the liver right artery lord stem, the cancer of the gall bladder wanted to be super in early days the line choosing the liver right artery to the gall bladder artery infused to note a chemotherapy and lay gall bladder artery slender super chose into a difficulty, can use clear compare the sponge bolted the liver right artery distant branch to fill, Be infused to note by the liver right artery lord stem thereafter, medicine then the big part get into gall bladder artery.
The progress much infringed upon while expecting a gall bladder cancer to infringe upon liver right before the leaf segment, put to take care of to the liver right artery lord stem to infuse to note a chemotherapy at this time, can give attention to both gall bladder at first and deliver cancer and liver gradually in the meantime cancer.
The progress expects a gall bladder cancer to infringe upon liver also the liver door wait a lymphoid knot assignor, pipe needs to insert to total artery, infusing to note medicine can get into the liver proper artery, the gall bladder artery and stomach 12 bowel arteries and give attention to both gall bladder at first and delivered cancer, liver gradually in the meantime the lymphoid knot of cancer and liver 12 bowel ligamentses transfers a cancer.The lymphoid knot transfers the cooking stove oppression Dan way to still want to be worn the sting Dan way to lead to flow by skin to the Geng Zu jaundice, the bile duct extend or the Dan support inside the way transplant Shu.
2.The selectivity artery bolts to fill a treatment
Adapt to certificate and taboo certificate:Gall bladder cancer gradually liver, it is thus clear that gall bladder artery and the liver right artery fight a formation to fit together, such as can be super the oil anti-cancer medicine milk choosing to these to unusually fit together a providing blood stem of, canning go iodine bolt to fill a treatment.In early days gall bladder cancer, bolted to fill gall bladder artery to cause the gall bladder bad dead;The gall bladder cancer will take place a lymphoid knot assignor and bolt to fill to cause serious reaction of stomach and pancreas in the near future, above-mentioned two kinds of circumstances can not carry on bolting to fill a treatment.
Technique:Bolt to fill a treatment such as the artery of liver cancer, super the area choosing to put to take care of to the liver right artery stem, building a shadow to confirm for the cancer brings up blood vessel and in advance infuses to note a chemotherapy and bolts to fill by the iodine oil anti-cancer medicine milk thereafter and bolt to fill to generally use a 5~10 mls namely reach a satisfaction to bolt to fill effect.
Lend support to measure:
Pain in the ① town:The ache that bolts to fill a creation delivered sex liver cancer a little bit at first violent, effectively relieved pain is successfully bolted assurance for filling and can use painful in the town to substitute Ding such as the Mao all over as well as infuse to note 2% benefits many cards through the pipe department because of or 1% cards of Pu Lu relieved pain because of the 3~5 mls;②Other:Pay respects to liver cancer to bolt to fill a treatment contents.
(Two)whole body chemotherapy
Gall bladder cancer to various chemotherapy medicine all all sensitive, can hardly observe its curative effect, but continuously develop along with the chemotherapy medicine in recent years clinical in great quantities research, for cure for good after the Shu a chemotherapy and not ability surgical operation, or Shu behind relapse of sufferer, the chemotherapies all have certain curative effect.
Adapt to a certificate:①Not proper surgical operation or put to treat and each period patient;②Later period and extensively transfer, marrow, liver lung, heart and kidney function normal;③Surgical operation or put to treat to make stronger a treatment behind, or surgical operation, put to treat behind relapse or transfer of sufferer.
1.Unite a chemotherapy
(1)FAM project:
5-the FU 600 mgsm 2, the vein drop notes, the 1, 8, 29, 36th day;
ADM 30 mgsm 2, intravenous injection, the 1, 29th day;
MMC 6 mgsm 2, intravenous injection, the 10th day.
6 treat a distance on Monday, take a rest for 4~6 weeks, go the 2nd to treat a distance.25% is effective, the average existence expects for 8.4 months.
(2)FAB project
5-the FU 400~600 mgsm 2, the 1, 22th day, 200~400 mgsm 2, the 4, 26th day, the vein drop notes;
ADM 60 mgsm 2, the 1st day, 45 mgsm 2, the 22th day, intravenous injection;
The card doesn't take charge of the Ting 150 mgsm 2, intravenous injection.
4 weeks for a treat a distance.Curing efficient 40% is or so and exist for 11 months on the average.
(3)FM project
5-the FU 500 mgsm 2, the vein drop notes, the 1~3th day;
MMC 6 mgsm 2, intravenous injection, the 1~3th day.
The using a medicine is one period for 3 days and take a rest re-usable for 4~5 weeks once, 4~6 periods for a treat a distance.
2.The single medicine chemotherapy card doesn't take charge of Ting(BCNU):125 mgstime.The d, the vein intravenous drop, connects to use 3 times for on treating a distance, can go the second to treat a distance for partition 6~8 weeks.The main toxicity represses for marrow, much at use a medicine 8~10 weathers appear white cell and blood platelets to descend and use after the medicine and reach a lowest value for 6 weeks;Secondly respond for digest way, appear disgusted, vomit, minority of patients appear the liver function damage, valley C to turn ammonia Mao to go up etc..
The excellent blessing settles(UFT):Take orally, each time 4 slice, every day 3 times, 4~8 weeks for on treating a distance, the curative effect compares substitute add fluorine(FT-207) slightly high, poisonous side effect together 5-FU, but lighter.
Substitute to add fluorine(FT-207):This article is the derivatives of the fluorine urine Mi Ding, be mainly transfered to change into the fluorine urine Mi Ding by liver but rise function in the body, its function and fluorine wet the homology of Mi Ding, chemotherapy index number is fluorine urine 2 times that of Mi Ding, but toxicity only is it 15~16.This article takes orally to absorb good, keep on time as 12~20 hours, can evenly be distributed to liver, kidney, small intestines, Pi and brain.Method of using:200~400 mgstime, take orally, every day 3 times, 20~40 gs for a treat a distance.
Taboo certificate:
1.The whole body in bad shape companion has the quality of bad disease;
2.The one who have serious liver, kidney, heart and lung function obstacle;
3.The white cell reduces to 4 the ×s are 109 Ls, the blood platelets is smaller than 50 the ×s are 109 Ls, there is issue of blood inclining to;
4.There are other serious complications, such as severity infection, gall bladder bore hole, digest way bleed etc..