The cause of disease pathology of esophagus cancer

The oesophagus cancer(carcinomaofesophagus) is a scale-like in shape oesophagus epithelial malignant tumor and carried on sex to swallow the difficulty as its most typical clinical symptom.This disease is the mankind's one of the familiar malignant tumors.The our country is the high hair of the oesophagus cancer nation, is also the death rate of this disease the tallest nation.The whole world annually oesophagus cancer lately outbreak example about 310,400, but our country 167,200.

Cause of disease and outbreak mechanism oesophagus cancer really slices a cause of disease not clear.Obviously, environment and some carcinogens are important with the result that the cause of disease is plain.

(A)second nitric An compound and fungi toxin

Have already known that about 30 kinds of second nitric Ans can induct animal tumor now.Domestic also already the successfully applied A Xia second nitric An, the muscle An sour B ester second nitric An, AN E and second nitric An induct the oesophagus cancer of big rat with two ethyls second nitric An etc.s.The our country survey discovers that in Gao Fa Qu's food and drinking, the nitrate, second nitrate and second class An content show Zhao to increase Gao, and and increase on tare degree of local oesophagus cancer and oesophagus rare of fall ill the rate present just related.These materials easily synthesize second carcinogen nitric An in the stomach.

The cancer-causing function of fungi toxin is early noticed by people.Our country the research result of the Lin Xuan2 oesophagus cancer prove, various mildewed changes the food can produce chemistry carcinogen, sickle germ, whitely the fungis such as fungi, yellow song fungi and black song fungi etc. not only can restore the nitrate as second nitrate, and can increase the content of second class An, promote synthesizing of second nitric An.Corn noodles through inoculate and after culturing sickle germ or yellow song fungi, the content of second class An can increase several, among them A radicle Xia radicle second nitric An for induct a big white rat oesophagus cancer of especially different carcinogen.The local scholar also discovers that infringe upon skin cell of the oesophagus of part in the close by fungi, can present simplicity to increase to living, light degree to weigh a degree not the typical model increase to living, even obvious of the cancer change.Hint fungi infection and divide, split up an unusually different stage to contain close contact on skin cell of oesophagus.Also discover in the meantime, at the oesophagus home position cancer increase to living beside can separate the pure stub that hopes futilely bead germ inside the skin.Therefore someone thinks and has the fungi of cancer-causing potential to continuously infringe upon skin of oesophagus over a long period of time, may cause or may be in conjunction with other cancer-causing factors but help the cancer to change, the past oesophagus fungi disease may be an oesophagus cancer of before the cancer one of the pathological changeses.The sour pickled cabbage is the Lin Xuan2 residents' a kind of main non-staple foodstuff, often drive whitely the fungi severity pollute but imply the nitrate of high density and second nitrate and second class An, thin layer the color compose the analysis can discover to imply second nitric An.The data also proves that edible of the sour pickled cabbage quantity and oesophagus cancer of the outbreak lead just related.Withdraw liquid and inspissation liquid to feed big white rat with the sour pickled cabbage over a long period of time, also confirm to have the function is to the oesophagus cancer.

(Two)the oesophagus hurt, oesophagus disease and the incitement function of food

The oesophagus hurts and some oesophagus diseases can urge hair oesophagus cancer.At causticity oesophagus burn and narrow, oesophagus Ben door lose idle disease and oesophagus Qi room or anti- flow sex of in the oesophagus burning sufferer, the outbreak of oesophagus cancer leads more general crowd is Gao.According to calculate is because be detained inside the oesophagus but to long term of chronic burning disease, ulcer, or chronic stimulate, then increase to living on skin of oesophagus, finally cause cancer's changing.The Epidemiology survey discovers that oesophagus cancer Gao Fa region's residents have the habit to take a meal very hot food, drink strong drink, eat a great deal of pepper and chew betel nut or cut tobacco, these chronic physics and chemistry incitements that glue a film to the oesophagus, all can cause partial top skin cell to increase to living.The animal experiment proves that fill the air skin of sex or cooking stove in the bureau increase to living may be a before the cancer expecting of the oesophagus cancer pathological changes.

(Three)malnutrition and trace element lack

Absorbing the animal egg white shortage and vitamin A, B2 and C to lack is the common characteristics of the oesophagus cancer food of Gao Fa Qu residents.But mostly the high hair region of malnutrition, oesophagus cancer not Gao Fa, past this isn't likely to be a predominant factor.The our country Epidemiology survey expresses that lacking iron is anemic, the egg white lacks to lack some chemical elements inside disease or soil, like Mu, copper, Peng, zinc, magnesium and iron etc., all may with oesophagus cancer indirectly relevant.The Mu is the important composition of the plant nitrate revivification Mao, lacking the Mu can make the nitrate in the plant body accumulated to gather.The applied spectrum analyzes 7 food samples of counties in Henan, discover oesophagus cancer region Lin Xuan2 of Gao Fa's food in, the content of Mu is lower than other counties.The applied catalyst pole table method analyzes the Mu content of Lin Xuan2 Ren's hair, serum and urine liquid all show Zhao is lower than other counties of the oesophagus cancer low hair area.

(Four)inherit a factor

The outbreak of oesophagus cancer often expresses the household gathering phenomenon.The survey in the our country provinces, such as mountain west, Shandong and river south...etc. discovers that have a male household history have 1/4~1/2 around.There is comparison Gao of male household history in Gao Fa Qu, among them, the paternity is the tallest, matriarchal society time it, the collateral branch is lowest.Live together time with household to have 1/2 in more than 20 yearses, but not and together living little then.This probably has something to do with the condition for living together, but cans not expels a heredity factor, either.Once discovered in England that two Capes of Zhang Zhi that have already shown sex heredity turned disease(keratosispalmarisetplantaris) household, in 48 members who had this kind of symptom, 18 people suffered from an oesophagus cancer.A village in Iran discovers 14 oesophagus cancers sufferer, its family tree is analytical in discover, 13 among those sufferer is same to the husband and wife's descendants.All of the 4, 5th generation members of this household suffers from an oesophagus cancer, and is taken bad age to show Zhao to advance.The chromosome mutation of the oesophagus cancer Gao Fa's household leads compare low hair household of Gao.These phenomenons explains that heredity and oesophagus cancer contain certain relation.