The symptom and treatment of hair cell leukemia

The hair cell leukemia(HCL) is a kind of seldom seen chronic leukemia and pass by and be called skin cell inside the white guts net to increase to living a disease.

This disease from 1958 Bouron1 e for the very first time report way, the abroad has already had a more research according to statisticsing its outbreak to lead to 0.2~0.5| 100,000 and takes up 2%~5% of all leukemias around.HCL is seen to middle age more male, the men and women compare to 4:1, the youngest case is 17 years old, the high peak age of outbreak is 40~50 years old, the course of illness length, condition thing have their order of priority is very inconsistent, the existence period of the Hou surname report way the shortest 1.5 months, grow for 11 years most .60% cases are tired and have fever, the half the number contains not normal jaundice and liver function, with the serum alkaline phosphoric acid Mao abnormality most is familiar.1|4~1|3 cases contain left stomach ache.70%~90% case beginnings had big swollen Pi while diagnosing, having 1| 4 cases around could have no symptom, just in the normal regulations check-up discover Pi being swollen big but confirm, the great majority case all has huge Pi and even fills with whole belly cavitieses and stretch a person basin chamber.About 1/2 patients have lightly, the mid-degree liver is greatly swollen and cause a vein high pressure's being as seldom seen as stomach water.Light degree the lymphoid knot is swollen big rare, majority of lymphoid knot not swollen big.1|3 cases have a skin to glue film issue of blood and purple Dian.

The sufferer can have different degree of anemic, also have the normal hemoglobin separately.The white cell can reduce as well as increase, the white cell amounts of the scope is from the 1.0-57.8 xls 09/rise, majority of cases have different degree blood platelets decrease, parts of cases present the typical model whole blood cell decrease, the whole blood cell decrease fastens to gradually make the marrow crocked up because of the hair cell and the Pi function Kang enter to.75%~90% cases have neutral grain cell to reduce, and often more obvious, the list checks the cell also obviously reduces, therefore very easily erupt various infection.

HCL diagnosis key is in the blood and(or) the marrow or drive gradually dirty machine such as find out characteristic hair cell in the spleen.

Cure:

(1)Pi resection:The spleen is the main source of hair cell, therefore cutting off the Pi is effective treatment method, can quickly improve blood elephant and whole body circumstance after slicing Pi, past choose a treatment for the head of this disease.

(2)α -interferon:Have the report way the lymphoid female cell interferon to adoption mankind to cure 17 hair cells a leukemia, measuring for the 3 xls is 07 units/ per sky, or the 6 X107 unit following day the muscle note and treat a distance for 4~24 weeks.All cases are used after the medicine for 2~14 weeks, the hair cell disappearance, hemoglobin and blood platelets in blood go up, 14 neutral grain cells increases, 2 spleens narrows to not ability Men and, therefore the interferon may become have no spleen swollen big choose a treatment after the Pi resection with the head relapsing, this therapy toxicity function isn't obvious.

(3)chemotherapy:8 HCL sufferers takes lump can rather(4 milligrams of|sky)6 months, 7 meet with an obvious improvement;The author applies the mildewed plain or soft erythromycin treatment originally disease;As well the useful big amount of unites the chemotherapy one who acquire to alleviate.

(4)the white cell exchange Shu:Be applicable to difficult cure type or the outside week blood of the sufferer of white cell Gao.

(5)the marrow transplant.

(6)strengthen the machine body immunity dint:To decrease infection effective.