The cause of disease of pancreas cancer

Currently, cause of disease and outbreak mechanism of pancreas cancer are clearly still not quite, a great deal of research expresses recently, the occurrence of the pancreas cancer probably has something to do with following factor.
1, smoke cigarette a great deal of of the research support having close contact between smoking and pancreas cancer.The smoking causes the possible mechanism of pancreas cancer:①The smoking urges the carcinogen tobacco particularity N-the second nitrate secrete bile duct, the anti- inflow Yi takes care of later on;②Tobacco particularity N-the second nitrate can go into pancreas with the blood to the particularity function of organ;③Smoke cigarette increment blood fat level, urge hair pancreas cancer.Smoker probably because the cell A radicle turns level low but easily cancer-causing.The experiment confirmation that Stolzenberg waits keeps enough folic acid and the Mao Duo Quan density, can reduce the risk of smoking cigarette- related pancreas cancer.
2, drink alcohol after the of different races alcohol its pancreas cancer outbreak the rate as well has a dissimilarity.Wait observation alcohol and American black and the white man pancreas cancer outbreak and lead a relation according to Silverman of research suggest, compared with the white man, the black male loves to drink and the female mid-degree alcohol all have a higher incidence rate.
3, diabetes test a research to express, the insulin is outside the body or can urge a pancreas cancer inside the body cell growth;The high density insulin can make the insulin kind growth factor-1 is activated by body, produce to include a cell period progress change of the growth promote an effect.
4, the research of chronic pancreatitis Epidemiology and member Epidemiology mostly support chronic pancreatitis to develop into the pancreas cancer.The Friess research suggests that in 5600 genes, in the expression decrease in the pancreas cancer and the chronic pancreatitis sufferer, 34 genes 157 genes express to build up in the chronic pancreatitis, and among them of 152 genes are in the pancreas cancer also the expression strengthen.This research proved that chronic pancreatitis and pancreas cancer may exist some contact from the member level.
5, You door spiral rod bacteria(Hp) research suggests, there is Hp serum in the pancreas cancer sufferer masculine gender result, compare with matched control to show Zhao difference, hint that Hp infection and pancreas cancer contain relativity.
6, not the steroid anti- burning medicine(NSAID) have a research to suggest, take the department wood's women, the outbreak rate of pancreas cancer lowers, but research suggests, the normal regulations takes department the wood also can't lower the incidence rate of pancreas cancer, and pancreas cancer outbreak the risk may enlarge, to the possible mechanism of this phenomenon BE:①Department the wood's fat to different organization oxygen match the influence of Mao different, may lower some risks of cancers, and then increase the risk of a little bit another cancers.②Department possibility wood have something to do with pancreatitis risk increment, but pancreatitis again with high pancreas cancer risk relevant.In fact, the application includes non- particularity COX depressant and the particularity depressant COX-2 prevention and cure a many digest way tumor, like etc. of oesophagus cancer, stomach cancer and colon cancer, all obtain better clinical and experiment result.But NSAID really slices a function to still need a further research to the pancreas cancer.
7, coffee survey discover, coffee can make to suffer from a pancreas cancer of dangerous increase 400%.The research proves that coffee can repress DNA a repair and the inducement has the silk abruption the process, is the main reason that it causes cancer before DNA makes duplicate completion.
The gene Notch, ras and p of the relationship with pancreas cancer outbreak 53, the Wu related etc. gene of TGF-β , DPC4 and Diao is very complicated in the function in the pancreas cancer, but the accurate mechanism is still not clear.Occurrence and development of tumor are many stage processes of complications, is a related various tumors gene to express to disorder probably many tumor repressor genes to lose to live to.The DNA chip technique can directly examine a mRNA category and abundant degree, is the emollient tool that studies a gene expression.